20220908104426 20220908104426 Selcuk Medical Journal sinandemircioglumd@gmail.com Prof. Dr. Sinan DEMİRCİOĞLU Selcuk Medical Journal Selcuk Med J 2149-8059 09 08 2022 38 3 DUYGU YILDIRIM Since the identification of SARS-CoV-2, a multisystem inflammatory syndrome (MIS-C) that appears in children after COVID-19 disease and mimics Kawasaki disease was reported in the UK in April 2020, while it is associated with Covid-19 in adults. Multisystem inflammatory syndrome (MIS-A) was reported in June 2020. MIS-A patients have been reported to be up to 50 years of age in the literature and are more likely to have some underlying health condition and have recently had an identifiable respiratory disease compared to MIS-C. On the other hand, MIS-A patients and MIS-C patients have many overlapping clinical features, but the severity of cardiac dysfunction, incidence of thrombosis, and MIS-A mortality may be higher in MIS-A. While it is clear that neutrophilia, lymphopenia, and thrombocytopenia are common in MIS-C/A, these features, together with elevations in troponin and BNP/NT-proBNP, have been considered measures of disease activity . 09 08 2022 156 164 10.30733/std.2022.01556 https://selcukmedj.org/en-us/adult-multisystem-inflammatory-syndrome-mis-a-associated-with-sars-cov-2-infection-literature-review-en-7138/ https://app.selcukmedj.org/uploads/makale-pdf/2021-124-723548435.pdf MERVE KOKU GÜLŞAH BARĞI Aim: The prolonged process of new coronavirus disease (COVID-19) and related restrictions cause physical inactivity, fear of COVID-19, and fatigue in individuals. During the pandemic, kinesiophobia may raise fear of death and physical inactivity in patients. However, kinesiophobia and its relationship with physical activity (PA), fear of COVID-19, and fatigue in individuals have not been known yet, which was therefore aimed to investigate in the current study . Patients and Methods: Adult individuals (n=166, 36.3±15.37 years) were included in the study. Kinesiophobia (Tampa Scale of Kinesiophobia), PA levels (International Physical Activity Questionnaire- Short Form), fear of COVID-19 (Fear of COVID-19 Scale (FCS-19)), and fatigue (Numeric Rating Scale) were evaluated remotely between 3 June 2021 and 30 June 2021 th rough an online platform. Results: Of the individuals, 91 (54.8%) had a high level of kinesiophobia, 55 (33.1%) were inactive, 84 (50.6%) were minimally active, and 27 (16.3%) were very active. Kinesiophobia score was significantly correlated with age, weight, body mass index, education level, and walking, total PA, FCS-19, and fatigue scores (p<0.05). Conclusion: Kinesiophobia and physical inactivity are prevalent in many individuals. Although individuals have no disease during the COVID-19 pandemic, their kinesiophobia level increases as walking, physical activities, and education levels decrease. Kinesiophobia also increases as age, weight, body mass index, fear of COVID-19 and fatigue increase. Considering the negative effects of kinesiophobia and the prolonged pandemic process, individuals should be urgently dire cted to P A counseling programs. 09 08 2022 106 113 10.30733/std.2022.01557 https://selcukmedj.org/en-us/kinesiophobia-physical-activity-fear-of-covid-19-and-fatigue-in-adult-individuals-a-cross-sectional-study-en-7139/ https://app.selcukmedj.org/uploads/makale-pdf/2022-4-861338052.pdf HANDE ÇAĞLIYAN HATİCE SOLAK RAVİYE ÖZEN KOCA BURCU GÜLTEKİN Z SOLAK GÖRMÜŞ Aim: Morphine is one of the most preferred opioids in treatment of chronic pain. Recurrent use can cause addiction. There is no consensus on cardiovascular system treatment/side effects of opioids. In order to investigate effects of opioid addiction on heart, myocardial contractility/histological changes were investigated in rats via experimental morphine addiction/withdr awal. Materials and Methods: 32 adult male Wistar albino rats used for study, which was officially completed on 28-05-2021, were divided into Control(C), Morphine(M), Morphine+Naloxone(MN) groups randomly. In GroupC 10mg/kg 0.9% NaCl solution, in GroupM-MN 10mg/kg morphine were administered subcutaneously for 7 days. After the last administration of morphine, 3mg/kg NaCl was given to GroupC-M, 3mg/kg naloxone was given to GroupMN intraperitoneally. Signs of morphine withdrawal were observed for 30 minutes and scored. 3-4mm strips of atria were hung in isolated organ bath chambers. Tension was adjusted to 2g. Adrenaline-induced contractions (0.001M) were observed. Changes in tension were recorded. SAS University Edition 9.4 program was used for statistical analysi s. Results: Morphine withdrawal behaviours were observed in GroupMN. There was no statistically significant difference between atrial contractility tension values of GroupC-M-MN(p>0.05). Pre-adrenaline tension values were higher in GroupM-MN than in GroupC. But the greatest contraction increase between 15minutes before/after adrenaline-induced data was in GroupC. Conclusion: Morphine addiction/withdrawal didn’t cause inotropic/chronotropic changes. No histological differences were observed in mast cells. These results may constitute a positive resource for the heart for systems analysis in morphine addicts. 09 08 2022 128 135 10.30733/std.2022.01558 https://selcukmedj.org/en-us/does-experimental-morphine-addiction-in-rats-change-physiological-and-histological-characteristics-of-the-heart-en-7140/ https://app.selcukmedj.org/uploads/makale-pdf/2022-10-429444075.pdf ABDULLAH YAZAR FATİH AKIN AHMET KILIÇ MEHMET UYAR AYŞEGÜL ZAİMOĞLU ALPER YILDIRIM Aim: The aim of the study was to evaluate the clinical features and consultation process of the patients who were consulted from the pediatric emergency department to the surgical departments during the pandemic period, and to compare the findings with the data before the pa ndemic. Patients and Methods: The research was conducted between 11.03.2020-11.03.2021 in the pediatric emergency department of our hospital. The enrolled patients at 0-18 years of age were retrospectively evaluated in terms of gender, age, diagnosis, consultation result, consultation response time. Our study was compared with the prepandemic data between 01.01.2019 and 31.12 .2019. Results: Of the patients; 42,4% were female and 57,6% were male. The mean age was 6,9±4,9 years. It was determined that 27,3% of our patients were consulted to one of the surgical clinics with the diagnosis of foreign body, 22,2% acute abdomen, 10.6% foreign body aspiration. It was found that 38,5% of the patients were consulted to the pediatric surgery department, 33,9% to the otolaryngology department and 11,4% to the thoracic surgery department. The mean consultation response time was 72,2±48,8 minutes. The distribution of diagnoses, consultation response time, consulted surgical departments, consultation results by age groups, and distribution of the consultation response times by surgical departments during the pandemic were found to be statistically significant compared to the pre-pandemic pe riod (p<0,05). Conclusion: In our study, it was found that the number of patients admitted to the pediatric emergency department decreased during the pandemic period, the number of hospitalizations increased, the diagnoses associated with trauma and close physical contact decreased, and the diagnosis of epididymorchitis increased. In addition consultation response times were observed to be con siderably longer. 09 08 2022 121 127 10.30733/std.2022.01559 https://selcukmedj.org/en-us/consultations-to-surgical-departments-in-pediatric-emergency-department-in-covid-19-pandemic-en-7141/ https://app.selcukmedj.org/uploads/makale-pdf/2022-27-868734892.pdf ALPER KIRILMAZ HALUK YAKA TAHSİN ÇOLAK HALİL SEMİZ AHMET KEKEÇ https://orcid.org/0000-0003-2045-4686 Aim: The aim of this study is to examine whether the timing of surgery in our elderly patients with a diagnosis of hip fracture changed before and after the pandemic, and whether this situation caused an increase in mortality . Patients and Methods: The patients who were operated with the diagnosis of hip fracture between March 2019 and March 2020 in our hospital database were accepted as in the pre-pandemic period, and the patients who were operated with the diagnosis of hip fracture between April 2020 and April 2021 were considered as in pandemic period. Both groups were statistically compared in terms of age, gender, waiting time for surgery , length of hospital stay and one year mortality . Results: When the factors af fecting mortality were examined, the time elapsed until surgery significantly increased mortality. While the mean waiting time for surgery was 27.6±19.4 hours in all patients, it was 25.7±19.1 hours in Group 1 and 29.6±19.6 hours in Group 2 and there was a significant difference between the two groups (p=0.043). The cut-off value of the waiting time for surgery, which caused mortality, was determined as “23.35” hours. While no significant increase in mortality was found in Group 1 (p=0.340), the increased delay for surgery in Group 2 affected mortality significantly (p=0.027). Conclusion: In this study, it was found that the increase in the delay of admission for surgery over 23.35 hours in the elderly population after hip fractures was directly associated with one year of mortality and also we think that the waiting time for surgery in the pandemic conditions is one of the factors that negatively af fect mortality in these patients. 09 08 2022 136 142 10.30733/std.2022.01560 https://selcukmedj.org/en-us/the-effect-of-waiting-time-for-surgery-after-hip-fractures-and-the-covid-19-pandemic-on-mortality-en-7142/ https://app.selcukmedj.org/uploads/makale-pdf/2022-45-491804194.pdf YEŞİM TUNÇ CEMAL AKSOY NURULLAH TÜRE Aim: It was aimed to investigate podcast awareness and frequency of use among otorhinolaryngologists on a national scale. Patients and Methods: This study was conducted via the open web address of 'Google forms' (Mountain View, CA) between 2021-2022. On a national scale, the intended audience consisted of otorhinolaryngologists of all ages and levels of experience. Ou r survey consisted of twenty questions. Results: In our study, the number of people who answered our questions was 112 (92 men (82.1%), 20 women (17.9%). When asked if they had listened to podcasts about otorhinolaryngology, 23 people (20.5%) answered that they had listened and 89 people (79.5%) had not. When people want to learn about a topic in the field of Otorhinolaryngology before pandemic, the most frequently used literature resources are 40.2% (n=45) books and 31.3% (n=35) e-books. It was observed that the most frequently used literature sources in the pandemic were 30.4% (n=34) online meetings and 27.7% (n=31) e-books. There was a statistically significant difference between the frequency distribution of resources consulted before and during the pandemic (p<0.001). Conclusion: Although the ongoing pandemic has affected the frequency of consulted to literature resource, it has not caused a significant change in podcast usage. The authors hope that this article will create an awareness for producing Turkish podcasts in the field of otolaryngology . 09 08 2022 114 120 10.30733/std.2022.01561 https://selcukmedj.org/en-us/awareness-among-otorhinolaryngologists-of-literature-resources-survey-research-en-7143/ https://app.selcukmedj.org/uploads/makale-pdf/2022-50-942289581.pdf SEVİNÇ KALIN MEVLÜT HAKAN GÖKTEPE PINAR YILMAZ Aim: Chest radiography and thoracic computed tomography (CT) play an important role in the diagnosis and prognosis of sarcoidosis, a systemic granulomatous disease characterized by non-caseating granulomas. Pulmonary hypertension, a rare complication of the disease, can be seen in all stages. There is a strong correlation between pulmonary hypertension (PH) and an increase in the diameter of the main pulmonary artery (MPAD). In this study, we aimed to evaluate MPAD with multislice computed tomography (CT) examination for the early diagnosis of PH in patients with stag e II sarcoidosis. Patients and Methods: We measured the diameter of the main pulmonary artery on thorax CT in patients with stage II sarcoidosis, who were followed up in our hospital with a diagnosis of sarcoidosis between January-2018 and December-2021, with hilar lymphadenopathy and parenchymal changes in their imaging, and compared them with the control group, whose chest X-ray was normal and thorax CT scan was performed with nonspecific symptoms. We evaluated the relationship between the pulmonary artery pressures obtained by echocardiography and the diameter of the main pulmonary arte ry in patients with stage II sarcoidosis Results: We found a significant correlation between the increase in MPAD and pulmonary artery pressure measured by ECHO in patients with sarcoidosis compared to the control group, and the pulmonary artery diameter measured by CT in this patient group. Conclusion: We think that CT evaluation of pulmonary artery diameter in patients with sarcoidosis can guide the development of PH and therefore of fer an opportunity for early intervention. 09 08 2022 143 147 10.30733/std.2022.01562 https://selcukmedj.org/en-us/evaluation-of-main-pulmonary-artery-diameter-by-multislice-computed-tomography-in-patients-with-stage-ii-sarcoidosis-en-7144/ https://app.selcukmedj.org/uploads/makale-pdf/2022-56-748653508.pdf AYHAN DAĞDEMİR OĞUZ DİNÇER MURAT ELLİ CANAN ALBAYRAK İBRAHİM KARTAL Aim: In this study, we discuss the efficacy and safety of autologous hematopoietic stem cell transplantation (AHSCT) for high-risk pediatric solid-tumor patients based on 1 2 years of experience. Patients and Methods: The data of patients aged < 18 years with pediatric malignancies who underwent AHSCT between January 2009 and July 2021 at the Pediatric Bone Marrow Transplant Unit were evaluated retrospectively. Results: Fifty-one patients (24 girls and 27 boys; median age, 7.8 years; range: 0.5–18 years) were enrolled in the study; 20, 15, 8, 4, 2, and 2 patients had diagnoses of neuroblastoma, Ewing’s sarcoma, Hodgkin’s lymphoma, non-Hodgkin’s lymphoma, germ cell tumor, and soft tissue sarcoma, respectively. The median neutrophil and platelet engraftment times were 11 (8–45) and 16 (4–62) days, respectively, and the median hospital stay was 38 (17–67) days. The median follow-up time was 2.83 (0.12–10.81) years and the overall survival (OS) rate was 51.3 ± 10.3% for all patients; the median follow-up times and survival rates for the Ewing’s sarcoma and neuroblastoma cases were 2.63 (0.12–10.55) years and 64.2 ± 14.9%, and 2.81 (0.31–7.91) years and 42.8 ± 12%, respectively. All four patients who received the conditioning regimen of carboplatin, etoposide, and melphalan (CEM) died; 6 of 16 neuroblastoma patients who received the busulfan and melphalan (Bu/Mel) regimen as a conditioning regimen died: the median follow-up period of the Bu/Mel neuroblastoma patients was 3.08 (0.32–7.91) years and the OS rate was 55.1 ± 13.8%. Conclusion: Although the number of patients in this study was limited, AHSCT resulted in better survival for Ewing’s sarcoma and neuroblastoma cases than reported for those who did not undergo AHSCT in our clinic. 09 08 2022 148 155 10.30733/std.2022.01563 https://selcukmedj.org/en-us/autologous-hematopoietic-stem-cell-transplantation-in-pediatric-malignant-diseases-12-years-of-experience-en-7145/ https://app.selcukmedj.org/uploads/makale-pdf/2022-63-688651958.pdf